特発性血小板減少性紫斑病 (ITP) を合併した結腸癌の1例

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  • A CASE OF COLONIC CANCER ASSOCIATING WITH IDIOPATHIC THROMBOCYTOPENIC PURPURA

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A 63-year-old woman was admitted to the hospital because of hematochezia. Severe anemia and thrombocytopenia were noted (red blood cell 248×104/mm3, hemoglobin 5.8g/dl, hematocrit 19.6%, platelet count 0.8×104/mm3). The patient was diagnosed as sigmoid colon cancer associating with idiopathic thrombocytopenic purpura (ITP). Transfusion of 25 units of platelet was performed and a large dose of globulin 20g/day for 5 days, methylprednisolon 500-1000mg/day, and prednisolone 50mg/day were administered. When the platelet count increased to 25.2×104/mm3, splenectomy and sigmoidectomy with lymphnode dissection (D2) were carried out. After the surgery, abnormal bleeding did not occur and the postoperative course was uneventful. After discharge, the patient has been followed at outpatient clinic as of 6 month after the operation, and the plateletcount is kept at good level of 25.2×104/mm3 without taking predonisolone.<br>The large dose gulobulin regimen appears an extremely safe and useful method in preoperative management of surgical patients with ITP. It is possible to keep increased platelet level by splenectomy.

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