十二指腸水平脚stromal tumorの1例

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  • A CASE OF GASTROINTESTINAL STROMAL TUMOR OF THE DUODENAL THIRD PORTION

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A 49-year-old woman was admitted to the hospital because of epigastralgia and dizziness. An endoscopic examination of the upper gastrointestinal (UGI) tract revealed a submucosal tumor (SMT) with bleeding in the doudenal third portion. She underwent a partial resection of the duodenum including the tumor, with reconstruction after the fasion of duodeno-jejunostomy (end-to-side) using EEA. Eight months after the operation, no recurrence or stenosis of the anastomotic site was observed by endoscopy of the UGI tract. Barium meal did not show any disturbance of the passage. In this case gross findings of the resected material revealed a mass with both intra-and extra-canallicular extension but no evidence of invasion of the tumor into the pancreas.<br> Histological findings of the tumor showed that solid nests and neoplastic cells exhibited spindles with spindle nucleui. Mitosis of the nucleus was hardly detected. Immunohistochemical examinations were negative for smooth muscle actin (SMA) and desmin, and partially positive for S-100 protein and neuron specific enolase (NSE). We speculate that the tumor did not originate from smooth muscle tissue but from neural tissue and that it was a gastrointestinal autonomic nerve tumor (GANT).

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