Bisphosphonateが著効を示した乳癌多発骨転移の1例

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  • A CASE OF BREAST CANCER WITH MULTIPLE BONE METASTASIS IN WHICH BISPHOSNATE WAS VERY EFFECTIVE

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The case involved a 53-year-old woman there was a previous history of undergoing a right mastectomy (t1, n0) in 1983. After a disease-free interval of 10 years and 4 months, her back pain becarne worse in October 1993 and she was diagnosed as having multiple bone metastasis (without other metastases) by a bone scintigram at another hospital in May 1994. Thereafter her symptoms were gradually getting worse and eventually she could not leave bed (PS-4) in October of the same yean the patient was admitted to the hospital when C-PTHrP was as high as 66.6.pmol/L and hypercalcemia (Ca level of 15.2mg/dl) was confirmed. After admission a combination chemotherapy with bisphosphonate, duxorubicin, 5 FU, CPA, and MPA was conducted and a change in the bone metastasis picture from osteolytic to sclerotic response was observed with normalization in plasma caicium level. Eventually bone metastaticfoci disappeared. The patient has been strictly followed up on an ambulant basis in PS-O, as of about 17 months after the treatment. This paper descibes this case with a review of the literature.

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