Vestibular Function and Alcohol.

• Ujihara Hisamitsu

  Department of Neuropsychiatry, Kochi Medical School

Bibliographic Information

Other Title

• 神経薬理・シリーズ教育講座　９　　前庭機能とアルコール

Abstract

Alcohol affects the oculomotor system and postural reflex, and vestibular nuclei are thought to be involved in both. In the medial vestibular nucleus (MVN), alcohol potentiates the effect of T-aminobutylic acid (GABA). Spontaneously firing MVN neurons were examined for alcohol in a brain stem slice. GABA suppressed the spikes evoked by local stimulation in the MVN neuron at the IC50 of 2 mM. One-percent alcohol potentiated the inhibitory effect of GABA, and the IC50 decreased to about 0.3 mM. Acutely dissociated MVN neurons showed similar spontaneous activity. Alcohol (0.01%) also potentiated the inhibitory effect of GABA in this preparation. The vestibular nuclei were particularly sensitive to alcohol in the brain. Therefore, the effect of alcohol is thought to be based on the potentiation of the action of GABA.

Journal

• Equilibrium Research

  Equilibrium Research 59 (3), 171-177, 2000

  Japan Society for Equilibrium Research

Keywords

• alcohol
• vestibular nuclei
• GABA
• electrophysiology

Details

• CRID: 1390282679922360192
• NII Article ID: 10009417087
• NII Book ID: AN00001485
• DOI: 10.3757/jser.59.171
• ISSN: 1882577X
• ISSN: 03855716
• Web Site: https://search.jamas.or.jp/link/ui/2001038438
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed