中枢神経浸潤をきたした乳腺悪性リンパ腫の1例

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  • A case of primary breast lymphoma with involvement of the central nervous system.

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A 56-year-old woman was seen at the hospital because of a rapid swelling of the left breast on November Ist, 1999. There was a tumor 7cm in diameter in the A area of the left breast. Needle biopsy suggested malignant lymphoma. Because of the large size of the tumor, one course of systemic chemotherapy with CHOP was performed before a modified radical mastectomy. Histological diagnosis was diffuse, medium sized cell type, Bcell lymphoma.. After post-operative chemotherapy with CHOP two courses, she had discharged from the hospital. Thereafter the signs of relapse occurred in the right submandibular lymph nodes and on the skin of left chest, abdomen in mid-May. Therefore additional CHOP 5 courses were carried out. In mid-Octover, furafura feeling and vertigo started. Magnetic resonance imaging of the Brain showed involvement of the central nervous system (CNS). CNS involvement of malignant lymphoma is found in 9% of all non-Hodgkin lymphomas. It is a disease with very poor prognosis. We report the case together with a review of the relevant literature.

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