シスプラチン投与症例におけるＤＰＯＡＥ

• 高橋 辰

  東北大学医学部耳鼻咽喉科

• 大山 健二

  東北労災病院耳鼻咽喉科

• 池田 勝久

  東北大学医学部耳鼻咽喉科

• 和田 仁

  東北大学工学部機械電子工学科

• 高坂 知節

  東北大学医学部耳鼻咽喉科

書誌事項

タイトル別名

• Distortion Product Otoacoustic Emissions in Cisplatin Administered Patients.

抄録

Effect of antineoplastic agent, cisplatin (CDDP) on distortion product otoacoustic emissions (DPOAE) were measured in 4 young patients without any ear problems. All of them had orthopedic malignancies and had repeated CDDP administrations during the DPOAE measuring program. Dose dependent decrease of DPOAE level, especially in high frequencies and in low input primary levels, and partial recovery of them were obserued, where no apparent change in pure tone audiometry was detected. Although some limitations exist, early detection of cochlear damage by CDDP and other ototoxic agents is possible by DPOAE measurements. Further study to find better indexes that should reflect state of cochlear damage is necessary to make this method an easy and useful clinical indicator of ototoxicity.

収録刊行物

• ＡＵＤＩＯＬＯＧＹ　ＪＡＰＡＮ

  ＡＵＤＩＯＬＯＧＹ　ＪＡＰＡＮ 38 (3), 229-236, 1995

  一般社団法人 日本聴覚医学会

キーワード

• シスプラチン
• 耳毒性
• 外有毛細胞
• 蝸牛

詳細情報

• CRID: 1390282679814371840
• NII論文ID: 130003862324
• NII論文ID: 10009449844
• NII書誌ID: AN00000347
• DOI: 10.4295/audiology.38.229
• ISSN: 18837301
• ISSN: 03038106
• Web Site: https://search.jamas.or.jp/link/ui/1996042070
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可