口腔へん平上皮癌の予後不良因子としてのｐ５３遺伝子の特定領域（Ｌ２＋Ｌ３＋ＬＳＨ）における変異

DOI 参考文献29件
  • 山崎 裕
    北海道大学大学院歯学研究科口腔病態学講座口腔診断口腔内科学分野
  • 千葉 逸朗
    北海道大学大学院歯学研究科口腔病態学講座口腔診断口腔内科学分野
  • 平井 敦子
    北海道大学大学院歯学研究科口腔病態学講座口腔診断口腔内科学分野
  • 金田 泰幸
    北海道大学大学院歯学研究科口腔病態学講座口腔診断口腔内科学分野
  • 野谷 健一
    北海道大学大学院歯学研究科口腔病態学講座口腔診断口腔内科学分野
  • 福田 博
    北海道大学大学院歯学研究科口腔病態学講座口腔診断口腔内科学分野
  • 柏崎 晴彦
    北海道大学大学院歯学研究科口腔病態学講座口腔顎顔面外科学分野
  • 戸塚 靖則
    北海道大学大学院歯学研究科口腔病態学講座口腔顎顔面外科学分野
  • 飯塚 正
    北海道大学大学院歯学研究科口腔病態学講座口腔病理診断学・口腔病態解析学分野
  • 向後 隆男
    北海道大学大学院歯学研究科口腔病態学講座口腔病理診断学・口腔病態解析学分野

書誌事項

タイトル別名
  • Specific regions (L2, L3, LSH) of p53 mutations as poor prognostic factors in oral squamous cell carcinoma.

この論文をさがす

抄録

Mutations of the p53 tumor suppressor gene have been found in about 50% of all human cancers.<BR>The relation of p53 status to clinicopathological variables and prognosis has been evaluated; however, it remains controversial in most cancers. Recent studies suggest that malignant potential and biological properties may depend on the region of mutation. It has also been demonstrated that specific regions of mutations within the core domain of p53 protein correlate with poor prognosis in breast cancer, esophageal cancer and colon cancer. To clarify the correlation between mutations within the DNA binding surface regions of p53 and clinical outcome in patients with oral cancer, we analyzed p53 mutations in 91 fresh primary, resected specimens of oral squamous cell carcinomas (SCCs) by polymerase chain reaction-singlestrand conformation polymorphism (PCR-SSCP) and a yeast functional assay.<BR>p53 mutations were detected in 36 of 91 (40%) cases. No correlation was found between overall mutations in the p53 gene and clinicopathological variables, clinical outcome, or survival rate. The five-year cumulative survival rate of 18 patients with tumors that had p53 mutations within DNA-binding surface regions (L2, L3, LSH) was significantly lower (52.5%) than that of the 73 other patients (p=0.004). Multivariate analysis, showed that mutations within these regions were independent prognostic factors (p<0.05, hazard ratio=2.9).<BR>These data suggest that mutations within DNA-binding surface regions of p53 may be important prognostic factors in oral SCCs.

収録刊行物

参考文献 (29)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ