歯性感染症を契機として一過性Ｌｕｐｕｓ　Ａｎｔｉｃｏａｇｕｌａｎｔ陽性が見出された１例

DOI 被引用文献1件 参考文献16件

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  • A case of transiently positive lupus anticoagulant in a patient with dental infection.

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Lupus anticoagulant (LA) is defined as an autoantibody that inhibits phospholipid-dependent blood coagulation, without suppressing individual blood coagulation factors. We encountered a LApositive patient who needed surgical treatment. The patient was a 32-year-old woman who came to our hospital because of right cheek swelling. A right buccal abscess due to 76 periapical periodontitis was diagnosed on the basis of the clinical manifestations and radiographic findings. The activated partial thromboplastin time (APTT) was remarkably prolonged to 65.5 seconds. The blood platelet count, other peripheral blood variables, and chemical data were within the normal range. After performing the cross mixing test and rarefaction prothrombin time (PT) test, the patient was found to be LA positive. She had no autoimmune diseases, such as systemic lupus erythematosus, which frequently accompanies LA, and there was no history of drugs that could induce LA. Thrombosis or thrombocytopenia occur frequently in LA-positive patients. Therefore, we managed her condition during the perioperative period taking this problem into consideration. APTT normalized, and LA became negative after surgery. The transient LA positivity in our case was attributed to infection.

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