漢方薬による肝障害報告の再検討　　リンパ球幼若化試験偽陽性の問題と関連して

DOI Web Site 被引用文献13件 参考文献30件

書誌事項

タイトル別名
  • Review of the literature on Kampo-induced liver injury: In relation to problems of false-positivity on lymphocyte transformation test.
  • リンパ球幼若化試験偽陽性の問題と関連して

この論文をさがす

抄録

We reexamined previous literature on Kampo-induced liver injury in Japan. These diagnoses were reviewed, independently of results on lymphocyte transformation test, by examining time to onset, course after cessation of the suspect Kampo medicine, concomitant drugs, search for non drug causes, and response to readministration. Among a total of 58 cases in the literature, 8 cases were assessed as insufficiently documented, and 4 cases were assessed as probably unrelated. Authors of the literature described that the 4 cases (probably unrelated in this study) were diagnosed with Kampo-induced liver injury based on positivity on lymphocyte transformation test. Since several experimental studies reported the mitogenic activity of Kampo medicine, lymphocyte transformation test is unsuitable as a diagnostic method of Kampo-induced liver injury. To examine the correct incidence and clinical features of Kampo-induced liver injury, reports on Kampo-induced liver injury that have been diagnosed accurately should be accumulated further.

収録刊行物

  • 肝臓

    肝臓 43 (6), 282-287, 2002

    一般社団法人　日本肝臓学会

被引用文献 (13)*注記

もっと見る

参考文献 (30)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ