繰り返し侵害刺激に対して反応頻度が増加する網様体細胞

DOI Web Site 参考文献21件

書誌事項

タイトル別名
  • Repetitive noxious stimuli to the peripheral nerves enhancing activity of reticular formation neurons in the rat

この論文をさがす

抄録

   Neurons in the reticular formation (RF) of the brainstem are thought to participate in the transmission of nociceptive information, because they receive fibers of the spinothalamic tract. However, the role of RF for the pain mechanism remained to be studied. In the present study, extracellular single-unit activities were recorded from RF of the medulla oblongata elicited by mechanical and electrical noxious stimuli to either hind limb of anesthetized rats.<br>   Single-spike and multiple-spikes responding to single electrical stimulation were recorded in RF. Multiple-spikes were grouped into the following three types from the number of spikes and the latency of each spike. Type I had two to four spikes, and the latency of each spike was not constant. Type II had three to six spikes, and the latency of the first spike was constant. Type III had five to eight spikes, and the latency of each of first three spikes was constant.<br>   Noxious informations via Aδ- and C-fiber reached to laminae V-VIII and laminae I-II, respectively, of the spinal dorsal horn. Moreover, there were lamina V neurons projecting to lamina III-IV, and lamina III-IV neurons projecting to lamina I-II. The presence of three types suggests that informations from various cells of origin of spinoreticular tract converged on a single neuron of RF. Furthermore, the presence of three types suggests that repetitive electrical stimuli activate various-closed circuits between the RF regions, because each of the RF regions of midbrain, pons and medulla oblongata connected reciprocally. Considering that RF receives and projects ascending and descending fibers in the brain and the spinal cord and that RF has reciprocal connections among ipsilateral and contralateral regions, we assumed that multiple spikes of RF contribute continuously to facilitating pain perception.

収録刊行物

  • PAIN RESEARCH

    PAIN RESEARCH 17 (2), 75-84, 2002

    日本疼痛学会

参考文献 (21)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ