Differences in Mechanisms between Weight Loss-Sensitive and -Resistant Blood Pressure Reduction in Obese Subjects
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- MASUO Kazuko
- Department of Geriatric Medicine
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- MIKAMI Hiroshi
- Department of Community Health Nursing, Osaka University Graduate School of Medicine
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- OGIHARA Toshio
- Department of Geriatric Medicine
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- TUCK Michael L.
- Sepulveda VA Medical Center and the University of California at Los Angeles
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This study was conducted to clarify the mechanisms involved in the sensitivity for blood pressure (BP) reduction in response to weight loss. In particular, we focused on the contributions of sympathetic nervous system activity and fasting plasma leptin and insulin levels to BP levels during weight loss in obese subjects with weight loss-sensitive and -resistant BP reduction. Sixty-one young, obese untreated hypertensive men (HT) and 52 obese normotensive men (NT) were enrolled in a weight loss program consisting of a low caloric diet and aerobic exercise over a 24-week period. At entry and at week 24, body mass index (BMI), BP, plasma norepinephrine (NE), leptin and insulin were measured. Successful weight loss and BP reduction were respectively defined as a more than a 10% reduction in BMI or mean BP from baseline at week 24. More than 60% of subjects in either group successfully achieved weight loss by this definition. The percentage of subjects who successfully achieved BP reduction was higher (64%) among those subjects who achieved weight loss than among those who did not (22%). Plasma NE level at entry in subjects who failed to achieve BP reduction despite weight loss was significantly higher than that in subjects who succeeded in BP reduction. Plasma leptin and insulin levels were similar between subjects with and without BP reduction. In addition, the absolute decrement and percent decrement in plasma NE in subjects who succeeded in BP reduction were significantly greater than those in subjects who failed to reduce their BP. Absolute and percent decrements in plasma leptin and insulin were similar in both groups. These results suggest that individuals who are resistant to weight loss-induced BP reduction have more sympathetic overactivity both at the outset of and during weight loss. (Hypertens Res 2001; 24: 371-376)
収録刊行物
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- Hypertension Research
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Hypertension Research 24 (4), 371-376, 2001
日本高血圧学会
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詳細情報 詳細情報について
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- CRID
- 1390282679696545280
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- NII論文ID
- 10009564235
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- NII書誌ID
- AA10847079
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- COI
- 1:STN:280:DC%2BD3Mvms1ahsA%3D%3D
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- ISSN
- 13484214
- 09169636
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- PubMed
- 11510749
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 使用不可