WHO-Cardiovascular Disease and Alimentary Comprarison (CARDIAC) Study Group, Distribution of 24-hour Urinary Taurine Excretion and Association with Ischemic Heart Disease Mortality in 24 Populations of 16 Countries: Results from the WHO-CARDIAC Study

DOI PubMed 被引用文献15件 参考文献30件
  • YAMORI Yukio
    Department of Environmental Preservation and Development, Graduate School of Human and Environmental Studies, Kyoto University WHO Collaborating Center for Research on Primary Prevention of Cardiovascular Diseases, Graduate School of Human and Environmental Studies, Kyoto University
  • LIU Longjian
    Otsuka Department of International Preventive Nutritional Medicine, Graduate School of Human and Environmental Studies, Kyoto University WHO Collaborating Center for Research on Primary Prevention of Cardiovascular Diseases, Graduate School of Human and Environmental Studies, Kyoto University Geriatric Research Education and Clinical Center, Donald W. Reynolds Department of Geriatrics, University of Arkansas for Medical Sciences
  • IKEDA Katsumi
    Otsuka Department of International Preventive Nutritional Medicine, Graduate School of Human and Environmental Studies, Kyoto University WHO Collaborating Center for Research on Primary Prevention of Cardiovascular Diseases, Graduate School of Human and Environmental Studies, Kyoto University
  • MIURA Ayako
    Department of Life Long Health Promotion, University of the Ryukyus
  • MIZUSHIMA Shunsaku
    International Research Center of Medical Education, University of Tokyo WHO Collaborating Center for Research on Primary Prevention of Cardiovascular Diseases, Graduate School of Human and Environmental Studies, Kyoto University
  • MIKI Tomohiro
    Division of Life Science, Graduate School of Integrated Science and Art, University of East Asia
  • NARA Yasuo
    Division of Life Science, Graduate School of Integrated Science and Art, University of East Asia WHO Collaborating Center for Research on Primary Prevention of Cardiovascular Diseases, Graduate School of Human and Environmental Studies, Kyoto University
  • on Behalf of the WHO-Cardiovascular Disease and Alimentary Comparison (CARDIAC) Study Group

書誌事項

タイトル別名
  • Distribution of Twenty-Four Hour Urinary Taurine Excretion and Association with Ischemic Heart Disease Mortality in 24 Populations of 16 Countries: Results from the WHO-CARDIAC Study.

この論文をさがす

抄録

There is considerable interest in the association between taurine (2-aminoethanesufonic acid) and risk of ischemic heart disease (IHD), but little information has been made available on the distribution of taurine in populations around the world. The present study aimed to describe the differences in taurine excretion levels and their associations with IHD mortality rates in 24 populations in 16 countries worldwide. This was a multicenter cross-sectional study. In each center, 100 men and 100 women aged 48-56 years were selected randomly from the local populations. Twenty-four hour urinary taurine excretion was measured using an amino acid analyzer (Hitachi 835, Ibaragi, Japan). Age-adjusted IHD mortality rates in the relevant populations were calculated using the direct standard method. The results indicated that (a) percentiles 25%, 50% and 75% of the distributions of 24-h taurine excretion showed large variations in the study populations. Median values of taurine ranged from 191.6 μmol/day (St John, Canada) to 2,180.6 μmol/day (Beppu, Japan) in males, and from 127.5 μmol/day (Moscow, Russia) to 1,590.0 μmol/day (Beppu, Japan) in females. The highest overall median value of taurine was found in the Japanese population samples, followed by the Chinese samples (Shanghai and Taiwan). European, North American and oceanic Caucasians, however, had much lower median values of taurine, except in the cases of the samples from France and Spain. (b) Median values of taurine were significantly associated negatively with age-adjusted IHD mortality rates across the 24 study population samples in men (R2=0.42, p<0.01), and in women (R2=0.55, p<0.01). These negative associations remained significant after adjustment for serum total cholesterol, body mass index and urinary sodium to potassium ratios. In conclusion, the study provides, for the first time, a cross-sectional database on distribution of 24-h urinary taurine excretion in 24 population samples worldwide. A strong and inverse association between population levels of taurine excretion and IHD mortality was observed. (Hypertens Res 2001; 24: 453-457)

収録刊行物

被引用文献 (15)*注記

もっと見る

参考文献 (30)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ