Sulfidopeptide leukotrienes, but not thromboxane B_2 or histamine, are elevated in sputum during exacerbation of asthma

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Author(s)

    • FENG Wu
    • Second Department of Internal Medicine, Okayama University School of Medicine
    • KIMURA Goro
    • Second Department of Internal Medicine, Okayama University School of Medicine
    • TANIMOTO Yasushi
    • Second Department of Internal Medicine, Okayama University School of Medicine
    • SODA Ryo
    • Department of Allergy, National Minamiokayama Hospital
    • KATAOKA Mikio
    • Second Department of Internal Medicine, Okayama University School of Medicine
    • HARADA Mine
    • Second Department of Internal Medicine, Okayama University School of Medicine

Abstract

Although sulfidopeptide leukotrienes (sLT) are considered to play an important role in the pathogenesis of asthma, their precise action has not been elucidated in asthmatics during exacerbation. In the present study, we examined sputum concentrations of sLT from asthmatic patients in order to determine whether sLT are actively involved in the exacerbation of asthma. We also examined sputum levels of thromboxane (TX) B<sub>2</sub> and histamine because these mediators are considered to be as important as sLT. The induced sputa by 3% hypertonic saline inhalation were treated with high-performance liquid chromatography and levels of sLT, TXB<sub>2</sub> and histamine were measured with enzyme immunoassay kits. These compounds tended to be elevated in asymptomatic asthmatic patients compared with healthy controls, but the differences were not significant. Levels of sLT and TXB<sub>2</sub> showed no difference between atopic and non-atopic patients, but histamine levels were higher in atopic patients than in non-atopic patients. However, sputa during the exacerbation contained significantly higher levels of sLT than those during the asymptomatic state. In contrast, neither histamine nor TXB<sub>2</sub> showed any changes with exacerbation. These results suggest that sLT may be one of the most potent for mounting the exacerbation of asthma.<br>

Journal

  • Allergology International

    Allergology International 50(1), 21-28, 2001-03-01

    Japanese Society of Allergology

References:  31

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