Mold-specific IgE antibodies in relation to exposure and skin test data in schoolchildren.
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- Taskinen Taina
- National Public Health Institute
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- Laitinen Sirpa
- Kuopio Regional Institute of Occupational Health
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- Hyvärinen Anne
- National Public Health Institute
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- Meklin Teija
- National Public Health Institute
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- Husman Tuula
- National Public Health Institute
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- Nevalainen Aino
- Department of Health Evaluation Sciences, Penn State University, Hershey
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- Korppi Matti
- Department of Paediatrics, Kuopio University Hospital
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Background: he purpose of the present study was to compare mold specific IgE results with skin test and exposure data, as well as in relation to asthma and other allergic manifestations.<br> Methods: We performed skin prick tests (SPT) to 13 molds in 341 children from six schools and studied the microbial status of all school buildings. Subsequently, mold specific IgE was measured by enzyme immunoassay (EIA) to 10 molds in 31 of those chil-dren with a positive (≥3 mm) or weak SPT reaction (1-2 mm) and in 62 age- and sex-matched controls with no such reactions.<br> Results: Mold-specific IgE was elevated by EIA (> 0.35 IU/mL) to at least one of the 10 studied species in 12 children (39%) with and in two children (3%) without skin test reactions. The calculated prevalence of elevated mold-specific IgE was 5% in the non-selected and 10% in children selected by respiratory morbidity. Six children had IgE to the dampness-indicative mold Aspergillus fumigatus, five children had IgE to the common outdoor mold Cladosporium herbarum and four children had IgE to the uncommon, but highly allergenic, indoor mold Rhizopus nigricans. All 14 children who had elevated IgE to molds were boys, 13 had atopy by skin tests and 12 had either asthma or had wheezed. However, no species-specific association was found between IgE or SPT responses and exposure to molds.<br> Conclusions: Mold allergy, as assessed by IgE measurements or skin tests, is rare in children. School-aged asthmatic boys having exposed to indoor air dampness seem to form a susceptible group for mold allergy, being at risk for worsening of their asthma.<br>
収録刊行物
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- Allergology International
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Allergology International 50 (3), 239-245, 2001
一般社団法人日本アレルギー学会
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詳細情報 詳細情報について
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- CRID
- 1390282679609094016
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- NII論文ID
- 10009586100
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- NII書誌ID
- AA11091750
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- ISSN
- 14401592
- 13238930
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
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- 使用不可