皮質硬膜上から高空間分解能で誘発電位を計測するための微小多点ポリイミド表面電極の開発

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  • Polyimide Multiple-site Surface Microelectrode for Epidural Cortical Recording of High Spatial Resolution Evoked-potentials
  • ヒシツコウマク ジョウ カラ コウクウカン ブンカイノウ デ ユウハツ デンイ オ ケイソク スル タメ ノ ビショウ タテン ポリイミド ヒョウメン デンキョク ノ カイハツ

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High spatial resolution mapping of cortical evoked-potentials may offer efficient and less-invasive recording of overall neu-ronal activities. because the signals involve population of neurons' activities. This paper proposes and develops the multiple-site surface microelectrode that maps cortical evoked potentials with high spatial resolution, 32 recording sites over a 2-mm-square area, and each size of the sites is 100-μm-square. With lithographic technologies, the conductive gold layer is sandwiched between an insulating polyimide layer and a polyimide substrate. Unlike conventional silicon microelectrodes, the flexible polyimide substrate can follow the convex and pulsative cortical surface, and realize less-invasive epidural recording. The impedance of each site is around 75 kΩ at 1 kHz, proved small enough to detect reliable cortical signals. Through in vivo experiments on the rat auditory cortex, the electrode achieves significant auditory-evoked potential maps, which are useful for examining cortical functions and varieties of evoked potentials.

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