グルタチオン高含有酵母エキスのアセトアミノフェン誘発性肝障害に対する有効性

• 杉村 洋一郎

  協和発酵工業株式会社筑波研究所

• 山元 一弘

  協和発酵工業株式会社筑波研究所

書誌事項

タイトル別名

• The Protective Effect of Glutathione-Enriched Yeast Extract on Acetaminophen-Induced Liver Damage in Rats.
• グルタチオン コウ ガンユウ コウボ エキス ノ アセトアミノフェン ユウハツ

抄録

The effects of orally administered glutathione-enriched yeast extract were studied in a model of acute hepatotoxicity induced by a high intraperitoneal dose of acetaminophen in rats. The reduced glutathione (GSH)-enriched extract showed dose-dependent hepatoprotective effects which were associated with recovery of the liver GSH level. Because no hepatoprotective effects were obtained using bread yeast extract that contained only low levels of GSH, the GSH-enriched yeast extract was shown to be effective by serving as a useful precursor for GSH biosynthesis in the liver. Because the hepatoprotective effect of GSH-enriched yeast extract tended to be stronger than that calculated from its GSH contents, substances other than GSH might also have contributed. Oxidized glutathione (GSSG) -enriched yeast extract given orally also showed a hepatoprotective effect together with recovery of the liver GSH level.

収録刊行物

• 日本栄養・食糧学会誌

  日本栄養・食糧学会誌 51 (4), 189-193, 1998

  公益社団法人 日本栄養・食糧学会

キーワード

• reduced glutathione
• oxidized glutathione
• yeast extract
• acetaminophen

詳細情報

• CRID: 1390282681268956544
• NII論文ID: 10009712594
• NII書誌ID: AN00311992
• DOI: 10.4327/jsnfs.51.189
• ISSN: 18832849
• ISSN: 02873516
• NDL書誌ID: 4546697
• Web Site: http://id.ndl.go.jp/bib/4546697
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4546697
• Web Site: https://search.jamas.or.jp/link/ui/1999027688
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可