書誌事項
- タイトル別名
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- Regulatory Mechanisms of Gene Expression by Carbohydrates.
- タンスイカブツ ニ ヨル イデンシ ノ ハツゲン チョウセツ キコウ
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抄録
Dietary carbohydrates regulate the expression of genes involved in carbohydrate and lipid metabolism. Although this regulation may be mediated by insulin, there is a considerable amount of evidence indicating that carbohydrates or their metabolites, and not insulin itself, are directly involved in gene regulation. The L-type isozyme (LPK) gene of pyruvate kinase, an important glycolytic enzyme, is a good example. This gene is expressed in liver, kidney, small intestine, and pancreatic β-cells, and is stimulated by carbohydrates such as glucose and fructose at both the transcriptional and post-transcriptional levels. Two cis-acting regulatory elements named L-II and L-III are required for transcriptional stimulation of the LPK gene by carbohydrates. Although the L-III element is itself responsive to carbohydrates, L-II functions as an accessory element. Both nuclear factor 1 proteins and hepatocyte nuclear factor 4 bind to the L-II element. Further studies have suggested that the former is involved in carbohydrate stimulation of the LPK gene. However, the L-III element binding protein that is involved in carbohydrate regulation remains to be clarified. Available evidence suggests that the carbohydrate signaling pathway to the LPK gene includes a glucose metabolite, possibly glucose 6-phosphate or xylulose 5-phosphate, as well as phosphorylation and dephosphorylation mechanisms.
収録刊行物
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- 日本栄養・食糧学会誌
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日本栄養・食糧学会誌 52 (3), 167-173, 1999
公益社団法人 日本栄養・食糧学会
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詳細情報
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- CRID
- 1390001206293257728
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- NII論文ID
- 10009713382
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- NII書誌ID
- AN00311992
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- ISSN
- 18832849
- 02873516
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- NDL書誌ID
- 4771847
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可