カルノシンおよびトリ胸肉抽出物（チキンエキス）のマウス遊泳疲労回復力に対する効果

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  • Effect of Carnosine and Chicken Breast Extract(CBEX) on Ability to Recover from Exhaustion in Mice.
  • カルノシン オヨビ トリ キョウニク チュウシュツブツ チキンエキス ノ マウス ユウエイ ヒロウ カイフクリョク ニ タイスル コウカ

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We previously reported the effect of chronic feeding with chicken breast extract (CBEX) containing the histidine-related peptides anserine and carnosine on improvement of swimming endurance in mice. The present paper describes the immediate accumulation of carnosine in muscles (M. quadriceps femoris and M. gastrocnemius) and enhanced recovery from exhaustion in mice after a single oral administration of carnosine and CBEX. Swimming endurance times (ET1 and ET2) of mice were determined in an adjustable-current pool: ET1 is the period until exhaustion during the first session of swimming, and ET2 is that during the second session of swimming after a single oral administration of carnosine, CBEX, or physiological saline as a control and a 15-min break after the first swimming session. The ET2/ET1 value was regarded as a recovery index. The index for control mice (56.9±3.4%) was lower than that for mice administered carnosine (79.9±6.4%, significant at p<0.01) and mice administered CBEX (70.9±9.0%, p=0.09). In the carnosine-administered mice, increases in carnosine concentration and pH of the quadriceps femoris and gastrocnemius muscles were observed at 15min after administration. These results suggest that carnosine may enhance recovery from exhaustion due to its buffering capacity and that CBEX may be an effective source of carnosine.

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