Expression of ATP1AL1, a Non-Gastric Proton Pump, in Human Colorectum.

• Takahashi Yuji

  Department of Pharmaceutical Physiology, Faculty of Pharmaceutical Sciences

• Sakai Hideki

• Kuragari Mutsuko

• Suzuki Tomoyuki

• Tauchi Katsunori

• Minamimura Tetsuji

• Tsukada Kazuhiro

• Asano Shinji

• Takeguchi Noriaki

抄録

The expression of mRNAs encoding a human nongastric proton pump (ATP1AL1) in the colorectum was investigated. The real-time PCR gave significant levels of signals not only in the distal part of human colon and rectum, but also in the proximal part of the colon. ATP1AL1 mRNA was overexpressed in 12 out of 20 human colorectal adenocarcinomas compared with the level in the accompanying normal mucosa. It is noted that astonishing levels of the mRNA overexpression were found in 4 carcinomas, which were detected even by Northern blot. The very high levels of ATP1AL1 mRNA expression in some cancer tissues may be connected to an unknown specific pathophysiological condition.<br>

収録刊行物

• The Japanese Journal of Physiology

  The Japanese Journal of Physiology 52 (3), 317-321, 2002

  一般社団法人　日本生理学会

キーワード

• ATP1AL1
• colon
• cancer

詳細情報

• CRID: 1390001205040795136
• NII論文ID: 10010020642
• NII書誌ID: AA00691224
• DOI: 10.2170/jjphysiol.52.317
• COI: 1:CAS:528:DC%2BD38Xns1OksLg%3D
• ISSN: 18811396
• ISSN: 0021521X
• NDL書誌ID: 6296794
• PubMed: 12230809
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I6296794
• Web Site: https://search.jamas.or.jp/link/ui/2003058552
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可