<I>Interaction of chondroitin sulfate proteoglycans with selectins, CD44, and chemokines</I>

• Kawashima Hiroto

  Laboratory of Molecular and Cellular Recognition, Osaka University Graduate School of Medicine

Bibliographic Information

Other Title

• コンドロイチン硫酸プロテオグリカンとセレクチン/CD44/ケモカインの相互作用

Abstract

Proteoglycans are ubiquitous components of cell surface membranes, basement membranes, and extracellular matrices in various tissues. They belong to a family of macromolecules that consist of core proteins to which glycosaminoglycans (GAGs), sulfated polysaccharides, are attached. Because of the high sulfate and carboxyl group content of their GAG moieties, proteoglycans have strong negative charges. This property allows them to interact with a wide range of proteins, including growth factors, enzymes, cytokines, chemokines, lipoproteins, and adhesion molecules. In this article, I will focus on the interaction of chondroitin sulfate proteoglycans with L-and P-selectin and CD 44, and chemokines, all of which have been implicated in leukocyte trafficking, and will provide evidence that a nonspecific electrostatic interaction is not the sole factor determining the interaction. I will also discuss biological implication of the interaction of chondroitin sulfate proteoglycans with L-and P-selectin and CD 44, and chemokines.

Journal

• Ensho Saisei

  Ensho Saisei 22 (2), 95-104, 2002

  The Japanese Society of Inflammation and Regeneration

Keywords

• <I>proteoglycan</I>
• <I>glycosaminoglycan</I>
• <I>chondroitin sulfate</I>
• <I>selectin</I>
• <I>chemokine</I>

Details

• CRID: 1390282680158158464
• NII Article ID: 130003708770
• NII Article ID: 10010036891
• NII Book ID: AA11508953
• DOI: 10.2492/jsir.22.95
• ISSN: 18805795
• ISSN: 13468022
• Web Site: https://search.jamas.or.jp/link/ui/2002166230
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed