<I>Inhibitory actions of glucosamine on neutrophil functions</I>

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  • グルコサミンの好中球機能抑制作用とそのメカニズム

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Abstract

Glucosamine, an amino monosaccharide occurring naturally in the connective and cartilage tissues, contributes to maintain the strength, flexibility and elasticity of these tissues. In recent years, glucosamine has been widely used to treat osteoarthritis in humans. Neutrophils, which usually function as the primary defenders in acute bacterial infections, are also implicated in the destructive inflammatory responses in arthritis. Recently, we have revealed the inhibitory actions of glucosamine on neutrophil functions. Glucosamine suppressed superoxide generation by neutrophils, and inhibited phagocytosis of opsonized particles. Furthermore, glucosamine inhibited the release of granule enzyme from phagocytosing neutrophils, and repressed chemotaxis. In addition, glucosamine significantly inhibited the upregulation of adhesion molecule CD 11 b, polymerization of actin and phosphorylation of p 38 MAPK, associated with neutrophil activation. Together these observations likely suggest that glucosamine suppresses the neutrophil functions, thereby exhibiting the anti-inflammatory actions in arthritis.

Journal

  • Ensho Saisei

    Ensho Saisei 22 (5), 461-468, 2002

    The Japanese Society of Inflammation and Regeneration

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