チアミラールの中心静脈からの投与が咳反射の発生頻度に及ぼす影響

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  • Higher Occurrence of Coughing Induced by Rapid Thyamilal Injection into the Central Vein.

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We investigated the effects of thyamilal's injection speed, injection routes and atropine premedication on the occurrence of coughing. We compared the incidence of coughing with rapid (about 2ml•sec-1) and slow (about 1ml•sec-1) thyamilal injection into the central vein and peripheral vein with or without atropine 0.5mg premedication. Rapid injection into the central vein caused a significantly higher incidence of coughing as compared with that of slow injection. Without atropine premedication, the incidence of coughing significantly reduced compared with atropine premedication under the same rapid thyamilal injection into the central vein. Rapid injection into the peripheral vein induced no cough reflex. Since coughing during anesthetic induction might cause serious complications, it is worth noting that rapid thyamilal injection into the central vein correlates to a high incidence of coughing and atropine premedication does not prevent it.

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