非ステロイド性抗炎症薬からみたキノロン系薬との薬物相互作用　　Ｇａｔｉｆｌｏｘａｃｉｎとｎｏｒｆｌｏｘａｃｉｎの比較検討

DOI 被引用文献7件 参考文献9件

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  • Convulsant activity of norfloxacin and gatifloxacin and interaction with antiinflammatory drugs.
  • Gatifloxacinとnorfloxacinの比較検討

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Quinolones have potent convulsant activity and that the activity is enhanced by the concurrent administration of anti-inflammatory drugs. We studied the effect of antiinflammatory drugs on the convulsant activity of norfloxacin (NFLX) and gatifloxacin (GFLX) to classify antiinflammatory drugs based on drug interaction with quinolones. Intraventricular injection of NFLX induced convulsions dosedependently in mice. The convulsant activity of NFLX was markedly enhanced by coadministration with biphenylacetic acid and flurbiprofen. Indomethacin and ketoprofen had intermediate enhancing activity, and loxiprofen and (-)-naproxen had weak activity. Mefenamic acid, sodium diclofenac, ibuprofen, tenoxicam, naproxen, aspirin and acetaminophen did not affect the activity. Intraventricular injection of GFLX induced convulsions dose-dependently in mice with weaker convulsant activity than NFLX. The convulsant activity of GFLX was weakly enhanced by coadministration of biphenylacetic acid. Other antiinflammatory drugs examined in this study did not affect the activity of GFLX. These results suggest that individual antiinflammatory drugs have different effects on drug interaction with quinolones.

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