Inhibition of Low-Density Lipoprotein Oxidation by Astaxanthin

• Iwamoto Tamami

  National Institute of Health and Nutrition

• Hosoda Kazuaki

  Institute for Fundamental Research Suntory Ltd.

• Hirano Reiko

  National Defense Medical College

• Kurata Hideaki

  Jikei University School of Medicine

• Matsumoto Akiyo

  National Institute of Health and Nutrition

• Miki Wataru

  Institute for Fundamental Research Suntory Ltd.

• Kamiyama Masumi

  Ochanomizu University Institute of Environmental Science for Human Life,

• Itakura Hiroshige

  National Institute of Health and Nutrition

• Yamamoto Shigeru

  Tokushima University

• Kondo Kazuo

  Ochanomizu University Institute of Environmental Science for Human Life,

抄録

Marine animals produce astaxanthin which is a carotenoid and antioxidant. In this study we determined the in vitro and ex vivo effects of astaxanthin on LDL oxidation. The oxidation of LDL was measured in a 1 ml reaction system consisting of increasing concentrations of astaxanthin (12.5, 25.0, 50.0 μg/ml), 400 μM V-70 (2, 2'-azobis (4-methoxy-2, 4-dimethylvaleronitrile)), and LDL (70 μg/ml protein). Astaxanthin dose, dependently significantly prolonged the oxidation lag time (31.5, 45.4, 65.0 min) compared with the control (19.9 min). For the ex vivo study 24 volunteers (mean age 28.2 [SD 7.8] years) consumed astaxanthin at doses of 1.8, 3.6, 14.4 and 21.6 mg per day for 14 days. No other changes were made in the diet. Fasting venous blood samples were taken at days 0, +14. LDL lag time was longer (5.0, 26.2, 42.3 and 30.7% respectively) compared with day O after consuming astaxanthin at doses of 1.8, 3.6, 14.4 and 21.6 mg for 14 days compared with day O, but there was no difference in oxidation of LDL between day O (lag time 59.9 + 7.2 min) and day 14 (57.2 ± 6.0 min) in the control group. Our results provide evidence that consumption of marine animals producing astaxanthin inhibits LDL oxidation and possibly therefore contributes to the prevention of atherosclerosis.

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ

  Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ 7 (4), 216-222, 2000

  一般社団法人 日本動脈硬化学会

キーワード

• Astaxanthin
• LDL oxidation
• Lag time
• Antioxidant

詳細情報

• CRID: 1390001204433350784
• NII論文ID: 130004104558
• NII論文ID: 10010269280
• NII書誌ID: AA11018976
• DOI: 10.5551/jat1994.7.216
• COI: 1:CAS:528:DC%2BD3MXktlCmur4%3D
• ISSN: 18803873
• ISSN: 13403478
• ISSN: http://id.crossref.org/issn/13403478
• PubMed: 11521685
• Web Site: https://www.jstage.jst.go.jp/article/jat1994/7/4/7_4_216/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2001258109
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可