Impact of Multiple Risk Factor Clustering on the Elevation of Blood Pressure.

DOI PubMed 被引用文献8件 参考文献66件
  • TOZAWA Masahiko
    Third Department of Internal Medicine and Dialysis Unit, University of the Ryukyus, Okinawa General Health Maintenance Association
  • ISEKI Kunitoshi
    Third Department of Internal Medicine and Dialysis Unit, University of the Ryukyus, Okinawa General Health Maintenance Association
  • ISEKI Chiho
    Third Department of Internal Medicine and Dialysis Unit, University of the Ryukyus, Okinawa General Health Maintenance Association
  • OSHIRO Saori
    Third Department of Internal Medicine and Dialysis Unit, University of the Ryukyus, Okinawa General Health Maintenance Association
  • HIGASHIUESATO Yasushi
    Third Department of Internal Medicine and Dialysis Unit, University of the Ryukyus, Okinawa General Health Maintenance Association
  • IKEMIYA Yoshiharu
    Third Department of Internal Medicine and Dialysis Unit, University of the Ryukyus, Okinawa General Health Maintenance Association
  • TAKISHITA Shuichi
    Third Department of Internal Medicine and Dialysis Unit, University of the Ryukyus, Okinawa General Health Maintenance Association

この論文をさがす

抄録

A family history of hypertension, obesity, diabetes mellitus, hypercholesterolemia, and hypertriglyceridemia have all been associated with risk of hypertension. We retrospectively conducted a longitudinal study in a large screened cohort to explore the effect of the clustering of these five risk factors on the elevation of blood pressure (BP) in normotensive subjects at baseline. The study group comprised 4, 857 normotensive subjects not treated with antihypertensive drugs (systolic BP <140 mmHg, diastolic BP <90 mmHg, 3, 111 men and 1, 746 women) who were followed up from 1997 to 1999. By 1999, 360 subjects had BP at the hypertensive level (systolic BP≥140 mmHg or diastolic BP≥90 mmHg). The incidence of subjects whose BP became hypertensive was 37 per 1, 000 person-years. After adjusting for age, sex, systolic BP and other clinical factors, multiple logistic analysis showed that the relative risk of BP elevation was 1.49 (95% CI: 1.09 to 2.05) in subjects with one risk factor; 1.65 (95% CI: 1.15 to 2.27) in those with two risk factors; 1.42 (95% CI: 0.91 to 2.32) in those with three; and 4.86 (95% CI: 2.58 to 9.16) in those with four or more when compared with subjects with no risk factors. Multiple regression analysis showed that the number of risk factors was positively correlated with an increase in BP from 1997 to 1999; the regression coefficient was 0.51 (p =0.001) for increase in systolic BP, and 0.31 (p =0.008) for increase in diastolic BP after adjusting for age and sex. In conclusion, clustering of risk factors significantly predicted the development of hypertension. (Hypertens Res 2002; 25: 811-816)

収録刊行物

被引用文献 (8)*注記

もっと見る

参考文献 (66)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ