肝臓の低潅流状態におけるＡＴ‐ＩＩＩの肝臓障害予防効果

• 瀧 健治

  佐賀医科大学救急医学講座

• 加藤 博之

  佐賀医科大学救急医学講座

• 平原 健司

  佐賀医科大学救急医学講座

• 大串 和久

  佐賀医科大学救急医学講座

• 戸塚 和敏

  佐賀医科大学救急医学講座

• 岩村 高志

  佐賀医科大学救急医学講座

書誌事項

タイトル別名

• Organ protecting action of AT-III for the liver-hypoperfusion injury

抄録

To determine the organ protecting action of AT-III, isotonic sodium chloride solution or AT-III were administered intravenously to the house rabbit hypoperfunion model before the portal vein was obliterated. We examined the changes in systolic blood pressure, regional blood flow of the liver, number of white blood cells and platelets, hepatic cell enzyme levels (GOT, GPT, and LDH), the activities of vasoeffective factors (PGI₂, NO, and endotheline), and arterial blood gases. After the obliteration discharge, the number of white blood cells didn't change though the regional blood flow and base exess (BE) returned to the values at the baseline, and the elevation of LDH was comparatively small in the AT-III group. As a result, AT-III could be recommended for prevention of liver-hypoperfusion injury by inhibition of accumulating white blood cells in the liver after the portal vein obliteration discharge.

収録刊行物

• 蘇生

  蘇生 22 (1), 13-18, 2003

  日本蘇生学会

キーワード

• 低灌流障害
• 臓器保護
• 肝臓

詳細情報

• CRID: 1390001206459357824
• NII論文ID: 10010760476
• NII書誌ID: AN10043787
• DOI: 10.11414/jjreanimatology1983.22.13
• ISSN: 1884748X
• ISSN: 02884348
• Web Site: https://search.jamas.or.jp/link/ui/2003252273
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可