２００１から２００２年に分離されたグラム陰性かん菌に対するカルバペネム系薬の抗菌力

DOI 被引用文献1件 参考文献14件

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  • Antibacterial activities of carbapenem antibiotics against clinical isolates of gram-negative rods.

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The susceptibilities of Pseudomonas aeruginosa, Haemophilus influenzae, Klebsiella pneumoniae, Enterobacter cloacae and Serratia marcescens to four types of carbapenems were examined using the broth micro-dilution method. All strains were isolated from various clinical samples obtained from patients of the Kawasaki Municipal Hospital between October 2001 and February 2002. An inoculum size of 105 cfu/mL was used.<BR>1. The MIC50S and MIC90S of the carbapenem antibiotics against 95 strains of P. aeruginosa were as follows: imipenem (IPM), 2μg/mL for MIC50 and 32μg/mL for MIC90; panipenem (PAPM), 8μg/mL and 32μg/mL, respectively; meropenem (MEPM), 1μg/mL and 8μg/mL, respectively; and biapenem (BIPM), 1μg/mL and 16μg/mL, respectively. The frequencies of strain resistance to IPM, PAPM, MEPM and BIPM (MIC≥16μg/mL) were 26.3%, 41.1%, 6.3% and 16.8%, respectively.<BR>2. The MIC50s and MIC90s of carbapenem antibiotics against 47 strains of H. influenzae were as follows: IPM, 1μg/mL for MIC50 and 4μg/mL for MIC90; PAPM, 1μg/mL and 4μg/mL, respectively; MEPM, 0.12μg/mL and 0.5μg/mL, respectively; and BIPM, 1μg/mL and 8μg/mL, respectively. The frequencies of strain resistance to IPM, PAPM and BIPM (MIC≥8μg/mL) were 2.1%, 6.4% and 10.6%, respectively. However, strain resistance to MEPM (MIC≥1μg/mL) was not observed.<BR>3. No carbapenem-resistant strains of K. pneumoniae, E. cloacae or S. marcescens were detected.<BR>4. We did not detect any strain of P. aeruginosa that could produce IMP-1 metallo β-lactamase. Although the number of carbapenem-resistant strains of P. aeruginosa did not increase significantly compared with past records, the continuous surveillance of resistance to carbapenem antibiotics in clinical isolates is important.

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