Azelnidipine and Amlodipine: a Comparison of Their Pharmacokinetics and Effects on Ambulatory Blood Pressure.
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- KURAMOTO Kizuku
- Tokyo Metropolitan Geriatric Hospital
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- ICHIKAWA Shuichi
- Cardiovascular Hospital of Central Japan
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- HIRAI Aizan
- Chiba Prefectural Togane Hospital
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- KANADA Shigeto
- Osaka Clinical Research Organization for Medicaments Clinic
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- NAKACHI Tetsu
- Tokyo Clinical Research Organization for Medicaments Bld.-Clinic
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- OGIHARA Toshio
- Osaka University Graduate School of Medicine
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We objected: 1) To compare the effects of azelnidipine and amlodipine on 24-h blood pressure; 2) To monitor the plasma concentration vs. the time profile in order to assess the association between pharmacokinetics and hypotensive activity after administration of either drug for 6 weeks. Blood pressure and pulse rate were measured by 24-h monitoring with a portable automatic monitor in a randomized double-blind study of 46 patients with essential hypertension. Azelnidipine 16 mg (23 patients) or amlodipine 5 mg (23 patients) was administered once daily for 6 weeks. Pharmacokinetics were analyzed after the last dose was taken. Both drugs showed similar effects on the office blood pressure and pulse rate. During 24-h monitoring, both drugs caused a decrease in systolic blood pressure of 13 mmHg and had a similar hypotensive profile during the daytime period (07:00-21:30). The pulse rate decreased by 2 beats/min in the azelnidipine group, whereas it significantly increased by 4 beats/min in the amlodipine group. Similar trends in the blood pressure and pulse rate were observed during the nighttime (22:00-6:30) and over 24 h. Excessive blood pressure reduction during the nighttime was not seen in either group. The pharmacokinetic results indicated that the plasma half-life (t1/2) of amlodipine was 38.5±19.8 h and that of azelnidipine was 8.68±1.33 h. Despite this difference in pharmacokinetics, the hypotensive effects of amlodipine and azelnidipine were similar throughout the 24-h administration period. (Hypertens Res 2003; 26: 201-208)
収録刊行物
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- Hypertension Research
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Hypertension Research 26 (3), 201-208, 2003
日本高血圧学会
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詳細情報 詳細情報について
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- CRID
- 1390282679697650816
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- NII論文ID
- 10010771811
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- NII書誌ID
- AA10847079
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- COI
- 1:CAS:528:DC%2BD3sXjt1ajtbo%3D
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- ISSN
- 13484214
- 09169636
- http://id.crossref.org/issn/09169636
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- PubMed
- 12675275
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可