Decreased Turnovers of Glutathione and Ascorbic Acid in Watanabe Heritable Hyperlipidemic Rabbits.

• SUZUMURA Kuniharu

  Department of Biochemistry, Osaka City University Medical School Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd.

• KASAHARA Emiko

  Department of Biochemistry, Osaka City University Medical School

• WANG Yi

  Department of Biochemistry, Osaka City University Medical School

• CHIEN Kuang-Chang

  Department of Biochemistry, Osaka City University Medical School

• INOUE Masayasu

  Department of Biochemistry, Osaka City University Medical School

抄録

Oxidative stress has been postulated to play important roles in the pathogenesis of various diseases such as atherosclerosis in hyperlipidemic subjects. Although the possible role of oxidation of low-density lipoprotein (LDL) in the etiology of atherosclerosis has been studied extensively, the turnover of endogenous antioxidants, which is an important protection system against oxidative stress, remains to be elucidated. The aim of our study was to determine the change of the turnover of endogenous antioxidants such as glutathione and ascorbic acid in case of hyperlipidemia, using Japanese white rabbits (JW) and Watanabe heritable hyperlipidemic rabbits (WHHL). The levels of total glutathione and low molecular weight thiols in the liver, kidney, and other organs in both strains of rabbits were similar. However, a kinetic analysis using L-buthionine-(S, R)-sulfoximine revealed that the rate of glutathione turnover in the liver and kidney of WHHL was about 50% lower than that of JW Furthermore, intravenously administered ascorbic acid disappeared more slowly in WHHL than in JW These results indicate that the turnovers of both glutathione and ascorbic acid in WHHL are depressed in comparison with that in JW. These changes would be closely related to the increased oxidizability of lipids in the circulation of hyperlipidemic subjects.

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ｎｕｔｒｉｔｉｏｎａｌ　Ｓｃｉｅｎｃｅ　ａｎｄ　Ｖｉｔａｍｉｎｏｌｏｇｙ

  Ｊｏｕｒｎａｌ　ｏｆ　Ｎｕｔｒｉｔｉｏｎａｌ　Ｓｃｉｅｎｃｅ　ａｎｄ　Ｖｉｔａｍｉｎｏｌｏｇｙ 46 (4), 205-209, 2000

  一般財団法人 学会誌刊行センター

キーワード

• antioxidant
• oxidative stress
• hyperlipidemia
• glutathione
• ascorbic acid

詳細情報

• CRID: 1390001206322514176
• NII論文ID: 10010804415
• NII書誌ID: AA00703822
• DOI: 10.3177/jnsv.46.205
• ISSN: 18817742
• ISSN: 03014800
• NDL書誌ID: 5531413
• PubMed: 11185659
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I5531413
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
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