Differential Induction of Protein Kinase C Isoforms at the Cardiac Hypertrophy Stage and Congestive Heart Failure Stage in Dahl Salt-Sensitive Rats

DOI PubMed 被引用文献1件 参考文献83件
  • KOIDE Yuichi
    Department of Medicine II, Yokohama City University School of Medicine Department of Molecular Biology, Yokohama City University School of Medicine
  • TAMURA Kouichi
    Department of Medicine II, Yokohama City University School of Medicine
  • SUZUKI Atsushi
    Department of Molecular Biology, Yokohama City University School of Medicine
  • KITAMURA Kouichi
    Department of Molecular Biology, Yokohama City University School of Medicine
  • YOKOYAMA Keiko
    Department of Medicine II, Yokohama City University School of Medicine
  • HASHIMOTO Tatsuo
    Department of Medicine II, Yokohama City University School of Medicine
  • HIRAWA Nobuhito
    Department of Medicine II, Yokohama City University School of Medicine
  • KIHARA Minoru
    Department of Medicine II, Yokohama City University School of Medicine
  • OHNO Shigeo
  • UMEMURA Satoshi
    Department of Medicine II, Yokohama City University School of Medicine

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Several protein kinase C (PKC) isoforms may play important roles in cellular signaling pathways. Recent reports have suggested that PKC plays critical isoform-specific roles in the development of cardiac hypertrophy and heart failure. The purpose of the present study was to examine the expression profiles of PKC isoforms in models of cardiac hypertrophy and heart failure. We examined the cardiac expression of individual PKC isoforms at the cardiac hypertrophy stage and the heart failure stage in Dahl salt-sensitive rats by Western blot analysis. The levels of all PKC isoforms increased at the cardiac hypertrophy stage and the heart failure stage, but the pattern of increase differed among PKC isoforms at the heart failure stage. The expressions of PKCα, β, and δ increased at the cardiac hypertrophy stage and remained elevated at the heart failure stage. On the other hand, the expression of PKCε and atypical PKCs (aPKCs) increased at the cardiac hypertrophy stage, but this increase tended to decline at the congestive heart failure stage. These results suggest that there are two groups of PKC isoforms. Several reports have shown that PKCα, β, and δ are involved in the development of cardiac hypertrophy and heart failure, and that PKCε plays a role in the physiological hypertrophic responses and cardioprotective actions. These facts suggest that all PKC isoforms (PKCα, β, δ, ε, and aPKCs) expressed in the heart may have similar functions at the cardiac hypertrophy stage, but that two groups of PKC isoforms (PKCα, β, δ, and PKCε, aPKCs) have different functions at the congestive heart failure stage. (Hypertens Res 2003; 26: 421-426)

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