Physical Characteristics of Finely Powdered Green Tea ―Preformulation Study for Solid Preparations Containing Green Tea Components

DOI 参考文献11件
  • Kurita Takurou
    Pharmaceutical Engineering, School of Pharmaceutical Science, University of Shizuoka
  • Miyagishima Atsuo
    Pharmaceutical Engineering, School of Pharmaceutical Science, University of Shizuoka
  • Nozawa Yasuo
    Pharmaceutical Engineering, School of Pharmaceutical Science, University of Shizuoka
  • Sadzuka Yasuyuki
    Pharmaceutical Engineering, School of Pharmaceutical Science, University of Shizuoka
  • Sonobe Takashi
    Pharmaceutical Engineering, School of Pharmaceutical Science, University of Shizuoka

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<p>Commercial green tea leaves were ground to a fine powder with a ceramic mortar and the powder characteristics were determined and evaluated for flowability using Carr's flowability index. The finely powdered green tea (PT) showed high compressibility of 49.1%, and a flowability index of 28.5 (flowability was “Very Poor”). By the addition of Perfiller®-101, the angle of repose and compressibility decreased and flowability was greatly improved, to the point of being sufficient for handling and dispensing. Released amounts of epigallocatechin gallate (EGCG) and caffeine from PT were about 10 times higher than those of unpowdered commercial green tea leaves. Additionally, the ratio of amount of EGCG to caffeine released from PT was higher than that from unpowdered commercial green tea leaves. Although the 50% release time of caffeine was shorter than that of EGCG from unpowdered commercial green tea leaves, there was little difference in the 50% release time of caffeine and EGCG from PT.</p>

収録刊行物

  • 薬剤学

    薬剤学 63 (2), 89-96, 2003

    公益社団法人 日本薬剤学会

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