Growth Response to Growth Hormone Therapy in Patients with Different Degrees of Growth Hormone Deficiency.

DOI Web Site PubMed 被引用文献5件 参考文献20件
  • FUJIEDA KENJI
    The Executive Scientific Committee of the International Cooperative Growth Study (ICGS) Japan
  • HANEW KUNIHIKO
    The Executive Scientific Committee of the International Cooperative Growth Study (ICGS) Japan
  • HIRANO TAKEKI
    The Executive Scientific Committee of the International Cooperative Growth Study (ICGS) Japan
  • IGARASHI YUTAKA
    The Executive Scientific Committee of the International Cooperative Growth Study (ICGS) Japan
  • NISHI YOSHIKAZU
    The Executive Scientific Committee of the International Cooperative Growth Study (ICGS) Japan
  • TACHIBANA KATSUHIKO
    The Executive Scientific Committee of the International Cooperative Growth Study (ICGS) Japan
  • TAKANO KAZUE
    The Executive Scientific Committee of the International Cooperative Growth Study (ICGS) Japan
  • TANAKA TOSHIAKI
    The Executive Scientific Committee of the International Cooperative Growth Study (ICGS) Japan
  • YOKOYA SUSUMU
    The Executive Scientific Committee of the International Cooperative Growth Study (ICGS) Japan

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抄録

Growth response to GH therapy in prepubertal patients with idiopathic GH deficiency (GHD) was analyzed in terms of the chronological age at the start of GH treatment and the GH secretory capacity, by using the large database provided by the International Cooperative Growth Study (ICGS) Japan. 1192 patients, aged from 3 to 10years were divided into three groups with the following maximum GH values in GH stimulation tests: Group A: both _??_5ng/ml, group B: both 5-10ng/ml, group C: one >10ng/ml. Analysis of age-related growth response using with delta height SDS (Δ height SDS) as a response variable revealed that the group A patients responded better to GH, while there was no differences between the other groups. Simple and multiple regression anlysis showed that IGF-I and chronological age (CA) negatively correlated with growth response, and target height SDS- height SDS positively correlated. These three most important predictors accounted for 49% of the variation in the growth response in group A, whereas six variables such as CA, frequency of GH injection, % overweight, GH dose, target height - height SDS, and pretreatment height velocity SDS accounted for only 28% of those in groups of B and C. These results lead us to conclude that growth response to GH is related to the degree of GH impairment with its cut-off level of 5ng/ml. From these findings it might be suggested that treatment regimen should be tailored to individual requirements according to the degree of GHD.

収録刊行物

  • Endocrine Journal

    Endocrine Journal 43 (Suppl), S19-S25, 1996

    一般社団法人 日本内分泌学会

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