Retinal Neurotoxicity of Nitric Oxide Donors With Different Half-Life of Nitric Oxide Release: Involvement of N-Methyl-D-aspartate Receptor

• Takahata Kazue

  Institute of Research and Development, Fujimoto Pharmaceutical Corporation

• Katsuki Hiroshi

  Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University

• Kume Toshiaki

  Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University

• Ito Ken

  Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University

• Tochikawa Yoshinaga

  Institute of Research and Development, Fujimoto Pharmaceutical Corporation

• Muraoka Shizuko

  Institute of Research and Development, Fujimoto Pharmaceutical Corporation

• Yoneda Fumio

  Institute of Research and Development, Fujimoto Pharmaceutical Corporation

• Kashii Satoshi

  Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Kyoto University

• Honda Yoshihito

  Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Kyoto University

• Akaike Akinori

  Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University

Abstract

We compared the degree of neurotoxic outcome in the retina exposed to three nitric oxide (NO) donors with different half-life of NO release. Intravitreal injection of NO donors resulted in a significant decrease in cell density in the ganglion cell layer and thinning of the inner plexiform layer in a half-life time-dependent manner. Concurrent injection of an NO-trapping reagent with an NO donor abolished NO donor-induced retinal damage. (+)-MK-801 also prevented NO-induced retinal damage, indicating that N-methyl-<sc>D</sc>-aspartate receptors are partly involved in NO-induced neurodegeneration. These results may be relevant to a pathogenic role of NO – glutamate receptor in several ophthalmic disorders.<br>

Journal

• Journal of Pharmacological Sciences

  Journal of Pharmacological Sciences 92 (4), 428-432, 2003

  The Japanese Pharmacological Society

Keywords

• nitric oxide
• neurodegeneration
• retina

Details

• CRID: 1390282680151814912
• NII Article ID: 10011432515
• NII Book ID: AA11806667
• DOI: 10.1254/jphs.92.428
• COI: 1:CAS:528:DC%2BD3sXmvFGlsb4%3D
• ISSN: 13478648
• ISSN: 13478613
• NDL BIB ID: 6656254
• PubMed: 12939529
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I6656254
• Web Site: https://search.jamas.or.jp/link/ui/2003316802
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed