老化促進モデルマウス (SAM) 顎関節下顎頭の加齢変化に関する免疫組織化学的研究

• 山田 耕治

  大阪歯科大学口腔外科学第1講座

書誌事項

タイトル別名

• Immunohistochemical studies of age-related changes in the mandibular condyle of the Senescence Accelerated Mouse (SAM)

抄録

This study describes an exomiaticn of the immunohistochemical localization of type I, type II and typeX collagens, and hyaluronic acid binding protein (HABP) in the mandibular condylar cartilage of SAMR1 (senescence accelerated mouse, resistant) and SAMP8 (senescence accelerated mouse, prone). The mandibular condyles were taken from 2, 4, 6, 8 and 10 month-old-female SAM.<br>In the condylar cartilage at 4 month-old SAMP8 compared with 2 month-old, the staining of type I collagen decreased in the intermediate and hypertrophic zone. Type II collagen not only increased in the hypertrophic zone but also in the articular and intermediate zones. Type X collagen was present in the pericellular matrix of the hypertrophic zone, and increased stain intensity located diffusely in the intermediate zone. HABP was present throughout the cartilage, and decreased in the intermediate and hypertrophic zones.<br>These changes were not observed in the 4 month-old SAMR1. These immunohistochemical changes were observed in the SAMP8 strain earlier than SAMR1, and thus this characteristic response may be related, at least in part, to accelerated senescence.

収録刊行物

• 日本顎関節学会雑誌

  日本顎関節学会雑誌 7 (3), 497-510, 1995

  一般社団法人 日本顎関節学会

キーワード

• 老化促進モデルマウス (SAM)
• 顎関節
• ピアルロン酸結合蛋白 (HABP)
• X型コラーゲン

詳細情報

• CRID: 1390282679398550400
• NII論文ID: 130003822126
• NII論文ID: 10011502630
• NII書誌ID: AN10093617
• DOI: 10.11246/gakukansetsu1989.7.497
• ISSN: 18844308
• ISSN: 09153004
• Web Site: https://search.jamas.or.jp/link/ui/1996125932
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可