Ｓｃｕｔｅｌｌａｒｉａ属の生薬による肝障害ならびに同属のオウゴン含有漢方処方による肝機能障害について

• 矢船 明史

  北里研究所バイオイアトリックセンター臨床薬理部 東京大学医学部薬剤疫学講座

• 津谷 喜一郎

  東京医科歯科大学難治疾患研究所情報医学研究部門臨床薬理学

書誌事項

タイトル別名

• Hepatic Injury Induced by Scutellaria Species and Hepatic Dysfunction Caused by Kampo Formulations Including Ogon (Scutellariae Radix).

抄録

There has been an increasing number of clinical reports in the West to suggest that hepatotoxic reactions can be induced by herbal preparations including skullcap of Scutellaria species. In Japan, the root of Scutellaria baicalensis (Scutellariae Radix) is used under the name of Ogon, which is included in many kinds of Kampo formulations, such as Sho-saiko-to widely used for treating hepatic disorders. Reviewing the Information on Adverse Reactions to Drugs published by the Ministry of Health and Welfare of Japan, we found 22 cases of liver and biliary system reactions caused by Kampo formulations from 1989 through 1993, and in 20 of the cases, six types of Kampo formulations including Ogon were suspected as the cause of the reactions. In two clinical reports of pulmonary damage due to Sho-saiko-to, Lymphocyte Stimulation Test indicated that Ogon was the causative factor for the damage. Although there have been no reports to indicate that Ogon can actually cause liver damage, the results of our review strongly suggest the necessity for surveillance of the possibility of hepatotoxic reactions caused by Ogon.

収録刊行物

• 臨床薬理

  臨床薬理 27 (3), 635-645, 1996

  一般社団法人 日本臨床薬理学会

キーワード

• 肝毒性
• 生薬成分含有製剤
• 漢方処方
• オウゴン

詳細情報

• CRID: 1390282680316665984
• NII論文ID: 10011506803
• NII書誌ID: AN0025404X
• DOI: 10.3999/jscpt.27.635
• ISSN: 18828272
• ISSN: 03881601
• ISSN: http://id.crossref.org/issn/03881601
• Web Site: https://search.jamas.or.jp/link/ui/1997067874
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可