2型糖尿病患者とHDLサブクラスとの関連性について

• 宍野 宏治

  愛媛大学医学部附属病院検査部

• 村瀬 光春

  愛媛大学医学部附属病院検査部

• 大沼 裕

  愛媛大学医学部臨床検査医学

• 櫃本 泰雄

  愛媛大学医学部臨床検査医学

• 大澤 春彦

  愛媛大学医学部臨床検査医学

• 牧野 英一

  愛媛大学医学部臨床検査医学

• 佐伯 修一

  愛媛大学保健管理センター

書誌事項

タイトル別名

• High Density Lipoprotein Subclasses Studied in Patients with Type 2 Diabetes Mellitus

抄録

We studied the qualitative changes of high density lipoprotein (HDL) subclasses in patients with type 2 diabetes mellitus using 8.5% polyacrylamide gel electrophoresis. The normal control subjects' HDL mainly consisted of HDL_2a with large particle sizes (41.4 ± 0.8% Mean ± SEM) and of HDL_3a with smaller parti-cle sizes (21.3 ± 0.5%). HDL2b, 3b and 3c were minor components in normal subjects. No signi-ficant differences were found between different genders or ages. In patients with type 2 di-abetes mellitus HDL2b and 2a (34.9 ± 1.2% p>0.001) decreased and HDL_3a (24.2 ± 0.6% p>0.001) increased compared with those in nor-mal subjects. The HDL sizes of patients with type 2 diabetes mellitus were estimated as smal-ler than those of normal subjects. The amounts of smaller size HDL subclasses in serum were not correlated with diabetic markers, but rather with the polydisperse LDL, hypo-HDL cholesterolemia, hypertriglyceridemia and arteriosclerosis index. Therefore, it was considered that the measurement of HDL subclasses in patients with type 2 diabetes mellitus was useful in the prevention and management of arteriosclerosis.

収録刊行物

• Japanese Journal of Clinical Chemistry

  Japanese Journal of Clinical Chemistry 29 (2), 61-68, 2000

  一般社団法人 日本臨床化学会

キーワード

• 型性低比重リポ蛋白
• リポプロテインA-I
• アポリポプロテインA-I
• 高トリグリセライド血症
• 低HDL血症

詳細情報

• CRID: 1390282679888368256
• NII論文ID: 130003357902
• NII論文ID: 10011546611
• NII書誌ID: AN00252758
• DOI: 10.14921/jscc1971b.29.2_61
• COI: 1:CAS:528:DC%2BD3cXksFOrtr0%3D
• ISSN: 21874077
• ISSN: 03705633
• Web Site: https://search.jamas.or.jp/link/ui/2000274470
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可