書誌事項
- タイトル別名
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- High Density Lipoprotein Subclasses Studied in Patients with Type 2 Diabetes Mellitus
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抄録
We studied the qualitative changes of high density lipoprotein (HDL) subclasses in patients with type 2 diabetes mellitus using 8.5% polyacrylamide gel electrophoresis. The normal control subjects' HDL mainly consisted of HDL2a with large particle sizes (41.4 ± 0.8% Mean ± SEM) and of HDL3a with smaller parti-cle sizes (21.3 ± 0.5%). HDL2b, 3b and 3c were minor components in normal subjects. No signi-ficant differences were found between different genders or ages. In patients with type 2 di-abetes mellitus HDL2b and 2a (34.9 ± 1.2% p>0.001) decreased and HDL3a (24.2 ± 0.6% p>0.001) increased compared with those in nor-mal subjects. The HDL sizes of patients with type 2 diabetes mellitus were estimated as smal-ler than those of normal subjects. The amounts of smaller size HDL subclasses in serum were not correlated with diabetic markers, but rather with the polydisperse LDL, hypo-HDL cholesterolemia, hypertriglyceridemia and arteriosclerosis index. Therefore, it was considered that the measurement of HDL subclasses in patients with type 2 diabetes mellitus was useful in the prevention and management of arteriosclerosis.
収録刊行物
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- Japanese Journal of Clinical Chemistry
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Japanese Journal of Clinical Chemistry 29 (2), 61-68, 2000
一般社団法人 日本臨床化学会
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詳細情報 詳細情報について
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- CRID
- 1390282679888368256
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- NII論文ID
- 130003357902
- 10011546611
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- NII書誌ID
- AN00252758
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- COI
- 1:CAS:528:DC%2BD3cXksFOrtr0%3D
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- ISSN
- 21874077
- 03705633
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可