腎移植患者の口腔症状についての臨床的研究

  • 根橋 克明
    日本歯科大学新潟歯学部口腔外科学教室第二講座
  • 又賀 泉
    日本歯科大学新潟歯学部口腔外科学教室第二講座

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タイトル別名
  • A Clinical Study on Oral Manifestations of the Patients Treated by Renal Transplantation.

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In 18 cases that underwent renal transplantation (RT), an epidemiological study was carried out mainly on changes in the oral symptoms such as gingival hyperplasia, salivary, and taste dysfunction before and after RT. Then individual changes were clinically and histopathologically, in part, assessed. The results were as follows:<BR>1. Hematoma previously observed on the oral mucosa disappeared after RT with improved anemic symptoms as well as dried lip and eye symptoms. Brown face characteristic of patients under hemodialysis was also improved.<BR>2. Hematological examination revealed that anemia was improved with decreased serum electrolyte levels, including potassium and inorganic phosphorus, after RT. Furthermore, the PTH level decreased markedly.<BR>3. As for changes that newly appeared after RT, gingival hyperplasia was observed in 6 out of 18 cases (33.3 %), which was histopathogically found to be fibrous hyperplasia in nature. Possible involvement of immunosuppressives or antihypertensives during pathogenesis was suggested.<BR>4. Subjective symptoms of xerostomia, which some patients complained of before RT, were improved in all cases after RT. Increased salivary flow at rest was observed objectively after RT. Salivary scintigraphy, performed in some cases, revealed an improved oral excretion capacity after loading with 10 % citric acid.<BR>5. Taste dysfunction observed before RT was improved in all cases after RT. A decreased threshold in 50 % of the cases was confirmed by a taste function test.<BR>6. Suppressed sweating was also improved in all cases after RT.<BR>7. Renal osteodystrophy (ROD) was obviously improved after RT with clearly depicted mandibular and pericondylar regions as well as recovered alveolar lumina dura on radiographs taken more than one year after RT.

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