グアニジン型キラル補助剤  [in Japanese] Chiral Guanidines  [in Japanese]

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Abstract

Guanidines easily react with not only acidic compounds but also electrophiles such as alkyl halides, to form the corresponding stable salts due to effective resonance. Thus, modified guani-dines could be expected to play important roles as chiral auxiliaries in asymmetric synthesis if chi-ral environment is produced in reactive salt intermediates. This article reviews the preparation of modified guanidines and their application to asymmetric synthesis. Reasonable asymmetric induc-tions were observed not only in catalytic but also in stoichiometric asymmetric syntheses. These guanidine-mediated reactions may contribute to development of green chemistry because of their possible uses as recyclable (economically favored) and easily functionalizable (widely applicable) auxiliaries.

Journal

  • Journal of Synthetic Organic Chemistry, Japan

    Journal of Synthetic Organic Chemistry, Japan 61(1), 58-66, 2003-01-01

    The Society of Synthetic Organic Chemistry, Japan

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