グアニジン型キラル補助剤

• 石川 勉

  千葉大学大学院薬学研究院 教授薬学博士

• 磯部 敏男

  白鳥製薬 (株) 技術部 課長

書誌事項

タイトル別名

• <I>Chiral Guanidines</I>
• グアニジンガタ キラル ホジョザイ

抄録

Guanidines easily react with not only acidic compounds but also electrophiles such as alkyl halides, to form the corresponding stable salts due to effective resonance. Thus, modified guani-dines could be expected to play important roles as chiral auxiliaries in asymmetric synthesis if chi-ral environment is produced in reactive salt intermediates. This article reviews the preparation of modified guanidines and their application to asymmetric synthesis. Reasonable asymmetric induc-tions were observed not only in catalytic but also in stoichiometric asymmetric syntheses. These guanidine-mediated reactions may contribute to development of green chemistry because of their possible uses as recyclable (economically favored) and easily functionalizable (widely applicable) auxiliaries.

収録刊行物

• 有機合成化学協会誌

  有機合成化学協会誌 61 (1), 58-66, 2003

  公益社団法人 有機合成化学協会

キーワード

• guanidine
• chiral auxiliary
• asymmetric catalysis
• kinetic resolution
• asymmetric synthesis

詳細情報

• CRID: 1390001205278877184
• NII論文ID: 10011904428
• NII論文ID: 40005652580
• NII書誌ID: AN0024521X
• DOI: 10.5059/yukigoseikyokaishi.61.58
• ISSN: 18836526
• ISSN: 00379980
• NDL書誌ID: 6431195
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I6431195
• データソース種別:
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  • NDL
  • Crossref
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