Liver Protection by Bis(Maltolato)Zinc(II) Complex
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- KAWASE Masaya
- Graduate School of Pharmaceutical Sciences, Osaka University
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- KAGAYA Noritaka
- Graduate School of Pharmaceutical Sciences, Osaka University
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- AKAMATSU Soh-ichiro
- Graduate School of Pharmaceutical Sciences, Osaka University
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- KAMIYOSHI Akiko
- Division of Laboratory Animal Research, Research Center for Human and Environmental Science, Shinshu University
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- MUTO Shin-ichi
- Toxicology Research Laboratory, R&D, Kissei Pharmaceutical Co. Ltd.
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- TAGAWA Yoh-ichi
- Division of Laboratory Animal Research, Research Center for Human and Environmental Science, Shinshu University
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- YAGI Kiyohito
- Graduate School of Pharmaceutical Sciences, Osaka University
Bibliographic Information
- Other Title
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- Liver Protection by Bis Maltolato Zinc 2 Complex
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Abstract
The aim of this study was to perform screening of a novel drug for treating liver injury. Bis(maltolato)zinc(II) complex [Zn(Mal)2], which was previously reported to possess insulinomimetic activity, was found to have potency against experimentally induced liver injury both in vitro and in vivo. Cultured rat hepatocytes were treated with bromobenzene for 24 h to induce cellular injury. Zn(Mal)2 of various concentrations was added along with bromobenzene in order to evaluate the hepatoprotective activity of Zn(Mal)2 in vitro. The number of viable hepatocytes decreased by 42% in the culture with bromobenzene. However, hepatocyte viability was maintained when Zn(Mal)2 was added to the bromobenzene culture. The hepatoprotective activity of Zn(Mal)2 in vivo was investigated using a concanavalin A-induced liver injury model in BALB/c mice. Changes in serum aminotransferase activities and the secretion of several cytokines were measured. The hepatoprotective effect of Zn(Mal)2 was also demonstrated in vivo by the suppression of serum aspartate aminotransferase and alanine aminotransferase elevation. No significant changes in serum cytokines associated with the induction of hepatic damage were observed in the concanavalin A-induced injury model. However, examination of concanavalin A-treated mouse splenocytes revealed a dose-dependent suppression of cytokine secretions by Zn(Mal)2. Zn(Mal)2 possessed hepatoprotective activity and might exert its effect by a number of mechanisms.<br>
Journal
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- Experimental Animals
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Experimental Animals 53 (1), 1-9, 2004
Japanese Association for Laboratory Animal Science
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Details 詳細情報について
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- CRID
- 1390001205042052736
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- NII Article ID
- 10011955822
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- NII Book ID
- AA11032321
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- COI
- 1:CAS:528:DC%2BD2cXisVahsLY%3D
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- ISSN
- 18817122
- 00075124
- 13411357
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- NDL BIB ID
- 6828587
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- PubMed
- 14993734
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed