Antiviral Activity of 2-Amino-4,4.ALPHA.-Dihydro-4.ALPHA.-7-Dimethyl-3H-Phenoxazine-3-One on Poliovirus

• Iwata Akiko

  Division of Cellular and Gene Therapy Products, National Institute of Health Sciences

• Yamaguchi Teruhide

  Division of Cellular and Gene Therapy Products, National Institute of Health Sciences

• Sato Kouei

  The Institute of Saitama Red Cross Center

• Izumi Ryutaro

  Office of Space Utilization Systems, Space Utilization Research Center, National Space Development Agency of Japan (NASDA)

• Tomoda Akio

  Department of Biochemistry, Tokyo Medical University

Abstract

2-Amino-4, 4α-dihydro-4α-7-dimethyl-3H-phenoxazine-3-one (Phx), which was produced by the reaction of bovine hemoglobin with 2-amino-5-methylphenol, inhibited the proliferation of poliovirus in Vero cells between 0.25 μg-/ml and 2 μg-/ml with maximal antiviral acitivity at 1 μg-/ml. These results suggest that Phx may be useful to prevent the proliferation of poliovirus infection.

Journal

• The Tohoku Journal of Experimental Medicine

  The Tohoku Journal of Experimental Medicine 200 (3), 161-165, 2003

  Tohoku University Medical Press

Keywords

• 2-amino-4, 4α-dihydro-4α-7-dimethyl-3H-phenoxazine-3-one
• poliovirus

Details

• CRID: 1390001204240128256
• NII Article ID: 10011990588
• NII Book ID: AA00863920
• DOI: 10.1620/tjem.200.161
• COI: 1:CAS:528:DC%2BD3sXot1Wjsbo%3D
• ISSN: 13493329
• ISSN: 00408727
• PubMed: 14521260
• Web Site: http://www.jstage.jst.go.jp/article/tjem/200/3/200_3_161/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2004242955
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed