Expression of heme oxygenase-1 in rat ontogeny

• Watanabe Takaoki

  Division of Cellular and Molecular Pathology, Niigata University Graduate School of Medical and Dental Sciences Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences

• Hasegawa Go

  Division of Cellular and Molecular Pathology, Niigata University Graduate School of Medical and Dental Sciences

• Yamamoto Takashi

  Division of Cellular and Molecular Pathology, Niigata University Graduate School of Medical and Dental Sciences

• Hatakeyama Katsuyoshi

  Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences

• Suematsu Makoto

  Department of Biochemistry, School of Medicine, Keio University

• Naito Makoto

  Division of Cellular and Molecular Pathology, Niigata University Graduate School of Medical and Dental Sciences

抄録

Heme oxygenase (HO), the heme-degrading enzyme, plays an important role in heme catabolism. Among three isozymes, HO-1 is an inducible form expressed mainly in macrophages. In rat ontogeny, HO-1 immunoreactivity was detected in mononuclear cells in the yolk sac at 10 days of gestation. HO-1-expressing cells were then detected in the fetal liver and their numbers increased during the gestational period. The numbers of HO-1-positive cells and HO-1 mRNA levels in the liver peaked at 18 days of gestation. Most of the macrophages expressed both HO-1 and a macrophage scavenger receptor. Macrophages in the fetal liver showed marked hemophagocytosis. Macrophages in the lung, spleen, bone marrow, and other tissues also expressed HO-1. HO-1 immunoreactivity was also observed in syncytial cells of the chorionic villi, the endodermal layer of the yolk sac, and renal tubules of the fetus. Intestinal mucosal epithelial cells expressed HO-1 after birth. These findings imply that HO-1 is crucial for macrophages in heme catabolism from an early stage of ontogeny. HO-1 expression in non-macrophagic cells may be required for other purposes such as protection from oxidative stress and various stimuli.

収録刊行物

• Ａｒｃｈｉｖｅｓ　ｏｆ　Ｈｉｓｔｏｌｏｇｙ　ａｎｄ　Ｃｙｔｏｌｏｇｙ

  Ａｒｃｈｉｖｅｓ　ｏｆ　Ｈｉｓｔｏｌｏｇｙ　ａｎｄ　Ｃｙｔｏｌｏｇｙ 66 (2), 155-162, 2003

  国際組織細胞学会

キーワード

• Histology

詳細情報

• CRID: 1390001206412947456
• NII論文ID: 130004462611
• NII論文ID: 10011992787
• NII書誌ID: AA1068990X
• DOI: 10.1679/aohc.66.155
• ISSN: 13491717
• ISSN: 09149465
• PubMed: 12846555
• Web Site: http://www.jstage.jst.go.jp/article/aohc/66/2/66_2_155/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2003307943
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可