The involvement of brain-derived neurotrophic factor (BDNF) in the regeneration of periodontal Ruffini endings following transection of the inferior alveolar nerve

DOI Web Site PubMed 被引用文献6件 参考文献74件
  • Harada Fumiko
    Division of Oral Anatomy, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences Divisions of Orthodontics, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences
  • Hoshino Natalia
    Division of Oral Anatomy, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences Divisions of Orthodontics, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences
  • Hanada Kooji
    Divisions of Orthodontics, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences
  • Kawano Yoshiro
    Division of Oral Anatomy, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences
  • Atsumi Yukako
    Department of Oral Anatomy and Developmental Biology, Osaka University Graduate School of Dentistry
  • Wakisaka Satoshi
    Department of Oral Anatomy and Developmental Biology, Osaka University Graduate School of Dentistry
  • Maeda Takeyasu
    Division of Oral Anatomy, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences

この論文をさがす

抄録

The present study employed immunohistochemistry for protein gene product 9.5 (PGP 9.5) to examine the regeneration process of Ruffini endings, the primary mechanoreceptor in the periodontal ligament, in heterozygous mice with targeted disruption of the brain-derived neurotrophic factor (BDNF) gene and their littermates, following transection of the inferior alveolar nerve. When immunostained for PGP 9.5, periodontal Ruffini endings appeared densely distributed in the periodontal ligament of the heterozygous mice, but the density of the positively stained nerve fibers in the ligament was 20% lower than that in the control littermates. At 3 days after surgery, the PGP 9.5-positive neural elements had disappeared; they began to appear in the periodontal ligament of both animals at 7 days. However, the recovery pattern of the PGP 9.5-positive nerves differed between heterozygous and wild type mice, typical periodontal Ruffini endings morphologically identical to those in the control group appeared in the wild-type mice at 7 days, whereas such Ruffini endings were detectable in the heterozygous mice at 28 days, though much smaller in number. On day 28, when PGP 9.5-positive nerves were largely regenerated in wild type mice, their distribution was much less dense in the ligament of the heterozygous mice than in the non-treated heterozygous mice. The density of PGP 9.5-positive nerve fibers was significantly lower in the heterozygous mice than in wild type mice at any stage examined. These data showing that a reduced expression of BDNF causes delayed regeneration of the periodontal Ruffini endings suggest the involvement of BDNF in the regeneration process of these mechanoreceptors.

収録刊行物

被引用文献 (6)*注記

もっと見る

参考文献 (74)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ