The Gene Encoding Muscle-Type Carnitine Palmitoyltransferase 1: Comparison of the 5'-Upstream Region of Human and Rodent Genes
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- Yamazaki Naoshi
- Faculty of Pharmaceutical Sciences, University of Tokushima
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- Yamanaka Yasuhisa
- Faculty of Pharmaceutical Sciences, University of Tokushima
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- Hashimoto Yoshiko
- Faculty of Pharmaceutical Sciences, University of Tokushima
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- Hiramatsu Takayuki
- Faculty of Pharmaceutical Sciences, University of Tokushima
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- Shinohara Yasuo
- Faculty of Pharmaceutical Sciences, University of Tokushima Institute for Genome Research, University of Tokushima Single-Molecule Bioanalysis Laboratory, National Institute of Advanced Industrial Science and Technology (AIST)
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- Terada Hiroshi
- Faculty of Pharmaceutical Sciences, Tokyo University of Science
書誌事項
- タイトル別名
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- The Gene Encoding Muscle-Type Carnitine Palmitoyltransferase I: Comparison of the 5'-Upstream Region of Human and Rodent Genes
- Gene Encoding Muscle Type Carnitine Palmitoyltransferase 1 Comparison of the 5 Upstream Region of Human and Rodent Genes
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抄録
Muscle-type carnitine palmitoyltransferase I (M-CPTI) is the key enzyme for fatty acid β-oxidation in heart and skeletal muscles and in adipose tissue. So far, M-CPTI mRNA has been detected in white adipocytes from epididymal fat pads of rats and humans, but not in mouse adipocytes. To characterize the gene expression of M-CPTI in mice, we isolated the genomic DNA encoding mouse M-CPTI and determined its transcription initiation site. As a result, the mouse M-CPTI gene seemed to have multiple initiation sites, as in the case of the rat and human genes. Furthermore, the con-served nucleotide sequence of the response element for peroxisome proliferators was shown to exist in the upstream of the mouse gene as in that of the rat and human genes. From these observations, we suggest that the anomalous expression of M-CPTI in mouse adipocytes reported previously may be regulated by factors other than peroxisome proliferators. Previously, we reported that there were transcripts containing regions of both CK/EK-β and M-CPTI genes in humans. In this study, we found that such transcripts also exist in rodents and that the amounts of the transcripts containing regions of both of these genes did not depend on the expression level of CK/EK-β.
収録刊行物
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- The Journal of Biochemistry
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The Journal of Biochemistry 133 (4), 523-532, 2003
社団法人 日本生化学会
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詳細情報 詳細情報について
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- CRID
- 1390001204964088960
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- NII論文ID
- 10012054265
- 130003534529
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- NII書誌ID
- AA00694073
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- COI
- 1:CAS:528:DC%2BD3sXkslajsLY%3D
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- ISSN
- 17562651
- 0021924X
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- NDL書誌ID
- 6519087
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- PubMed
- 12761301
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可