Inhibitory Effects of Hyssop (Hyssopus officinalis) Extracts on Intestinal α-Glucosidase Activity and Postprandial Hyperglycemia

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Author(s)

Abstract

It has been known that <i>Hyssopus offlcinalis</i> (hyssop) is a herb that grows in the wild and is a source of natural antioxidants. We previously reported that α-glucosidase inhibitors, (2<i>S</i>, 3<i>S</i>)1-O-β-D-6'-O-cinnamoylglucopyranosyl-3-(3'', 5''-dimethoxy-4''-hydroxy-phenyl)-1, 2, 3-propanetriol and (2<i>S</i>, 3<i>S</i>)1-O-β-D-glucopranosyl-3-(3'', 5''-dimethoxy-4 hydroxy-phenyl)-1, 2, 3-propanetriol, from the dry leaves of hyssop, were isolated. This study examined the α-glucosidase inhibitory effects of hyssop extracts on intestinal carbohydrate absorption in rat everted gut sac and carbohydrate-loaded hyperglycemia in mice. In the everted gut sac experiment, 10mM sucrose- and 5mM maltose-treated increases in glucose concentration in the serosal compartment were inhibited in the presence of 0.5 and 1.0mg/mL hyssop extracts, although a 10mM glucose-induced increase in serosal glucose was not inhibited by the extracts. Additionally, hyperglycemia in sucrose- and maltose-loaded mice was significantly suppressed at an early stage, within 30 to 60 min by oral pre-administration of 300 and 100mg/kg hyssop extracts, respectively. These findings suggest that hyssop extracts inhibited the digestion of complex carbohydrates, but not that of absorbable monosaccharide, and might be a useful supplemental food for hyperglycemia.

Journal

  • Journal of Nutritional Science and Vitaminology

    Journal of Nutritional Science and Vitaminology 49(5), 346-349, 2003-10-01

    Center for Academic Publications Japan

References:  13

Codes

  • NII Article ID (NAID)
    10012074238
  • NII NACSIS-CAT ID (NCID)
    AA00703822
  • Text Lang
    ENG
  • Article Type
    ART
  • ISSN
    03014800
  • NDL Article ID
    6730390
  • NDL Source Classification
    ZR2(科学技術--生物学--生化学)
  • NDL Call No.
    Z53-B484
  • Data Source
    CJP  NDL  J-STAGE 
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