New Beauvericins, Potentiators of Antifungal Miconazole Activity, Produced by Beauveria sp. FKI-1366: I. Taxonomy, Fermentation, Isolation and Biological Properties

DOI PubMed 被引用文献7件 参考文献19件
  • FUKUDA TAKASHI
    Kitasato Institute for Life Sciences & Graduate School of Infection Control Sciences, Kitasato University The Kitasato Institute
  • ARAI MASAYOSHI
    Kitasato Institute for Life Sciences & Graduate School of Infection Control Sciences, Kitasato University The Kitasato Institute
  • YAMAGUCHI YUICHI
    Kitasato Institute for Life Sciences & Graduate School of Infection Control Sciences, Kitasato University The Kitasato Institute
  • MASUMA ROKUROU
    Kitasato Institute for Life Sciences & Graduate School of Infection Control Sciences, Kitasato University The Kitasato Institute
  • TOMODA HIROSHI
    Kitasato Institute for Life Sciences & Graduate School of Infection Control Sciences, Kitasato University The Kitasato Institute
  • OMURA SATOSHI
    Kitasato Institute for Life Sciences & Graduate School of Infection Control Sciences, Kitasato University The Kitasato Institute

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  • I. Taxonomy, Fermentation, Isolation and Biological Properties

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Three new beauvericins, designated beauvericins D, E and F, were isolated along with known beauvericin and beauvericin A, from the culture of Beauveria sp. FKI-1366 by solvent extraction. ODS column chromatography and HPLC. These compounds potentiate miconazole activity against not only wild Candida albicans but also fluconazole resistant C. albicans. Beauvericins D and E decreased the IC50 value of miconazole against fluconazole resistant C. albicans from 1.3μM to 0.25 and 0.31μM, respectively.

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