イソフルレンがマウス脳虚血時のプロテインキナーゼＣとカルシウムカルモジュリン依存性プロテインキナーゼＩＩのトランスロケーションに与える影響

DOI 被引用文献1件 参考文献30件

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  • Clinical dose of Isoflurane prevents calcium/calmodulin dependent protein kinase II but not protein kinase C translocation to synaptic membrane in the ischemic mice brain

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PKC and CaMKII play important rolls in the neuronal intracellular signal transduction. During cerebral ischemia, both PKC-γ and CaMKII-α are translocated to synaptic membrane from cytosol. Some reports suggested that prevention of this translocation relates to the neuroprotection. In this study, using 2 min decapitation of cerebral ischemia model in mice, we demonstrated that in the 1 MAC or 2MAC isoflurane inhalation groups, CaMKII but not PKC translocation was significantly inhibited. These results suggest that isoflurane inhibits Thr 286 autophosphorylation of CaMKII. As conclusion, isoflurane may have neuroprotective action through the CaMKII signal transduction cascade.

収録刊行物

  • 蘇生

    蘇生 23 (1), 1-7, 2004

    日本蘇生学会

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