THERAPY OF PATIENTS WITH ORAL CANCER BASED ON THE REGULATION OF A TRANSCRIPTION FACTOR, NF-.KAPPA.B

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  • AZUMA Masayuki
    Second Department of Oral and Maxillofacial Surgery, Tokushima University School of Dentistry
  • SATO Mitsunobu
    Second Department of Oral and Maxillofacial Surgery, Tokushima University School of Dentistry

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  • 転写因子ＮＦ‐κＢの制御に基づいた口腔癌治療

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Abstract

We found that the tumor-forming ability in nude mice of the super-repressor form of IκBα (srIκBα) cDNA-transfected human oral squamous carcinoma cell (B88) clones (B88mI-1, -2, and -3) was significantly lower than that of B88 or empty vector-transfected cell clones (B88neo). This suppressed ability in tumorigenicity was attributed to the remarkable down-regulation of the expression of IL-1α, IL-6, IL-8, and VEGF in B88mI cell clones as compared to that in B88 or B88neo. When tumor-bearing nude mice were treated with ionizing radiation (IR) or 5-FU, the suppression of tumor growth was significantly augmented in B88mI cell clones as compared to that in B88 or B88neo. ELISA analysis indicated that although a remarkable increase in production of IL-6 and IL-8 was observed in B88 and B88neo after in vitro exposure to IR or treatment with 5-FU, radio- and chemotherapy-induced production of these cytokines was significantly suppressed in B88mI cell clones.

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