表面ガングリオシドの動力学および空間的配置

DOI Web Site 被引用文献3件 参考文献45件
  • Brocca Paola
    Study Center for the Functional Biochemistry of Brain Lipids, Department of Medical Chemistry and Biochemistry, The Medical School, University of Milan
  • Sonnino Sandro
    Study Center for the Functional Biochemistry of Brain Lipids, Department of Medical Chemistry and Biochemistry, The Medical School, University of Milan Dipartimento di Chimica e Biochimica Medica
  • 小倉 美佐
    東京医科歯科大学・医学部・分子医化学

書誌事項

タイトル別名
  • Dynamics and Spatial Organization of Surface Gangliosides.
  • ヒョウメン ガングリオシド ノ ドウリキガク オヨビ クウカンテキ ハイチ ガ

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Model surfaces in a water environment suitable for the study of membrane ganglioside properties have been developed. They, together with ganglioside micelles of large molecular mass, consist of ganglioside-phosphatidylcholine mixed micelles of small molecular mass and ceramide-modified ganglioside micelles of intermediate molecular mass. The experimental information on the conformational and geometrical properties of ganglio-series gangliosides inserted into these model surfaces is discussed, compared and integrated with that obtained using multilamellar aggregate models.<br>The results show that the conformational properties of the chain are determined by interresidual interactions between the sialic acid and N-acetylgalactosamine units, regardless of the total oligosaccharide structure, the structure of the ganglioside ceramide, possible phospholipid head group or Ca++ interactions, a highly enriched ganglioside environment, the presence of cholesterol in the membrane or temperature variation. Furthermore, the oligosaccharide chain seems to be well extended beyond the bilayer surface with a well defined average conformation and motional order, common to all the investigated gangliosides.

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