二経路投与法の超選択的動注療法による集学的治療

DOI 被引用文献19件 参考文献18件

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  • Two-route chemotherapy by superselective intraarterial infusion of high-dose cisplatin and STS for advanced head and neck cancer.

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Twenty-three patients with unresectable head and neck cancer and 13 to undergo neoajuvant chemotherapy were treated by two-route intraarterial chemotherapy using cis-diamminedichoroplatinum (CDDP) and sodium thiosufate (STS). In these patients, 100mg/m2 of CDDP was administered weekly through each feeding artery of the tumor superselectively at 5mg/min. During infusion of CDDP, STS of 200-fold of CDDP was injected through a catheter placed in the brachiocephic vein introduced via the subclavian vein. The complete and partial response rates were 26/36 (72%) and 10/36 (28%), respectively. Residual tumor could not be revealed histologically in 10 of the 13 patients following operation. Four of the recurrent 6 cases showed partial response, which could have been attributed to the inability to conduct superselective infusion. It was reported that all the patients were free from chemotoxicity such as renal and hematological dysfunction and each chemotherapy could be done weekly on schedule, and the treatment period between 1st intraarterial infusion and surgery was greatly shortened. Our two-route intraarterial chemotherapy can overcome advanced head and neck cancer with a high response rate. This new method of chemotherapy seems very efficient for advanced head and neck cancers.

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  • 頭頸部腫瘍

    頭頸部腫瘍 24 (3), 325-333, 1998

    日本頭頸部癌学会

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